Abby Barnes (Garofalo) is a veterinarian, who hosts a Los Angeles radio show called "The Truth About Cats and Dogs." The use of this as the title of the film also suggests the combative nature of male-female romantic relationships. Abby strikes up an unexpected friendship with her neighbor Noelle Sluslarsky (Thurman), a traditionally attractive model who is sweet, but not very sharp. When Abby makes a blind date with a caller to her show (Chaplin), her insecurity with her own appearance leads her to convince Noelle to pretend to be Abby when meeting the date. Unfortunately, both women develop feelings for the man, leading to a comedic series of misunderstandings, as the unintended consequences of their deception grow deeper.
Cast
| Actor | Role |
|---|---|
| Janeane Garofalo | Abby Barnes |
| Uma Thurman | Noelle Slusarsky |
| Ben Chaplin | Brian |
| Jamie Foxx | Ed |
| James McCaffrey | Roy |
| Richard Coca | Eric |
| Stanley DeSantis | Mario |
| Antoinette Valente | Susan |
| Mitch Rouse | Bee Man |
| David Cross | Male Radio Caller (voice) Bookstore Man |
| Mary Lynn Rajskub | Female Radio Caller (voice) |
| Bob Odenkirk | Bookstore Man |
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